Curriculum Vitae
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William K. Arnold Ph.D.
Updated [May 27, 2020]
PERSONAL DETAILS
wkarno2 at gmail.com
EDUCATION
Degree, University and location, Month/Year
B.S. Biology University of Kentucky May 2011
Ph.D. Microbiology, Immunology, and Molecular Genetics (July 2018)
PROFESSIONAL EXPERIENCE
Year(s), Job title, Location
April 2018 - Present, Senior QC Scientist - Addgene, Watertown, MA
May 2013 - July 2018, Graduate Research Assistant - Brian Stevenson Lab, Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY
February 2012 - August 2012, Research Technician - Jeramiah Smith Lab, Department of Biology, University of Kentucky, Lexington, KY
May 2011 - February 2012, Research Technician - Fred DeBeer Lab, Department of Physiology, University of Kentucky, Lexington, KY
May 2009 - May 2011, Research Assistant - Nancy Webb Lab, Department of Nutrition, University of Kentucky, Lexington, KY
PUBLICATIONS
Jutras, B.L., Savage, C.R., Arnold, W.K., Lethbridge, K.G., Carroll, D.W., Tilly, K., Bestor, A., Zhu, H., Seshu, J., Zückert, W.R., Stewart, P.E., Rosa, P.A., Brissette, C.A. and Stevenson, B. (2019), The Lyme disease spirochete’s BpuR DNA/RNA‐binding protein is differentially expressed during the mammal–tick infectious cycle, which affects translation of the SodA superoxide dismutase. Mol Microbiol, 112: 973-991. doi:10.1111/mmi.14336
Timothy Casselli, Yvonne Tourand, Adam Scheidegger, William K. Arnold, Anna Proulx, Brian Stevenson, Catherine A. Brissette. DNA Methylation by Restriction Modification Systems Affects the Global Transcriptome Profile in Borrelia burgdorferi. Journal of Bacteriology Nov 2018, 200 (24) e00395-18; DOI: 10.1128/JB.00395-18
Arnold WK, Savage CR, Lethbridge KG, Smith TC, 2nd, Brissette CA, Seshu J, Stevenson, B. (2018) Transcriptomic insights on the virulencecontrolling CsrA, BadR, RpoN, and RpoS regulatory networks in the Lyme disease spirochete. PLoS ONE 13(8): e0203286. DOI: 10.1371/journal.pone.0203286
Bobrov AG, Kirillina O, Fosso MY, Fetherston JD, Miller MC, VanCleave TT, Burlison JA, Arnold WK, Lawrenz MB, Garneau-Tsodikova S, Perry RD. 2017. Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice. Metallomics 9:757-772. doi.org/10.1039/C7MT00126F
Arnold WK, Savage CR, Brissette CA, Seshu J, Livny J, et al. (2016) RNA-Seq of Borrelia burgdorferi in Multiple Phases of Growth Reveals Insights into the Dynamics of Gene Expression, Transcriptome Architecture, and Noncoding RNAs. PLoS ONE 11(10): e0164165. doi: 10.1371/journal.pone.0164165
Woodman, M.E., C.R. Savage, W.K. Arnold, and B. Stevenson (2016) Direct PCR of intact bacteria (Colony PCR). In Current Protocols in Microbiology. J. Wiley and Sons, Hoboken, N.J., Appendix 3DB.
Savage CR, Arnold WK, Gjevre-Nail A, et al. Intracellular Concentrations of Borrelia burgdorferi Cyclic Di-AMP Are Not Changed by Altered Expression of the CdaA Synthase. Chang Y-F, ed. PLoS ONE. 2015;10(4):e0125440. doi:10.1371/journal.pone.0125440.
Arnold WK, Savage CR, Antonicello AD, Stevenson B. Apparent Role for Borrelia burgdorferi LuxS during Mammalian Infection. Infection and immunity 2015, 83(4): 1347-1353.
Doctoral Dissertation
Arnold, William Kenneth, “INSIGHTS INTO KEY GENE REGULATORY NETWORKS IN BORRELIA BURGDORFERI” (2018). Theses and Dissertations–Microbiology, Immunology, and Molecular Genetics. 19. doi.org/10.13023/etd.2018.493
PROFESSIONAL ORGANIZATIONS
Name of organization, year(s)
AAAS, 2016 - 2019
HONORS AND AWARDS
Name of award, year(s)
Domestic Travel Award – University of Kentucky – 2014
International Travel Award – University of Kentucky – 2015
Dissertation Enhancement Award – University of Kentucky – 2016
Sponsored AAAS Membership Award – Annual Membership to AAAS – 2016, 2017
Best Poster Award – Microbiology, Immunology, and Molec. Genetics Ann. Retreat - 2017
PROFESSIONAL SERVICE AND OUTREACH
Function, name of association, year(s)
Invited Reviewer – PloS One, FEMS Microbiology Letters, Frontiers Microbiology
Science Fair Judge - Fayette County Public Schools. 2015 - 2017
RELEVANT TRAINING AND COURSEWORK
Data Intensive Biology Summer Institute, 2017
Presentations
ORAL
International Symposium on Tick-Borne Pathogens and Disease. Vienna, Austria. September, 2017. Novel approaches shed light on transcriptome architecture and gene regulation in Borrelia burgdorferi: A new look at an old picture.
Microbiology, Immunology and Molecular Genetics Departmental Seminar. Lexington, KY. January, 2017. Dissection of gene regulatory networks in B. burgdorferi.
Microbiology, Immunology and Molecular Genetics Departmental Seminar. Lexington KY. November, 2016. Mechanistic links between bacterial growth rate and virulence.
Integrated Biomedical Sciences orientation day 3 Minute Thesis. Lexington, KY. August, 2015. Growth rate as a cue for virulence.
Microbiology, Immunology and Molecular Genetics Departmental retreat 3 Minute Thesis. Berea, KY. May, 2015. Growth rate as a cue for virulence.
Microbiology, Immunology and Molecular Genetics Departmental Seminar. Lexington, KY. November, 2015. Quorum sensing in the Lyme disease spirochete – A link between metabolic flux and virulence.
Microbiology, Immunology and Molecular Genetics Departmental Seminar. Lexington, KY. November, 2014. Giant Viruses shed light on viral evolution.
POSTER
Molecular Genetics of Bacteria & Phages. Madison, WI. August, 2017. Novel approaches shed light on transcriptome architecture and gene regulation in Borrelia burgdorferi: A new look at an old picture.
Microbiology, Immunology and Molecular Genetics Departmental Retreat. Lexington, KY. April, 2017. Replication linked expression of the RNA/DNA binding protein, bpuR.
Bacterial Locomotion and Signal Transduction. New Orleans, LA. January, 2017. Replication linked expression of the RNA/DNA binding protein, bpuR.
Midwest Molecular Pathogenesis Conference. Champagne, IL. September, 2016. Replication linked expression of the RNA/DNA binding protein, bpuR.
Molecular Genetics of Bacteria & Phages. Madison, WI. August, 2016. Replication linked expression of the RNA/DNA binding protein, bpuR.
Gordon Research Seminar & Conference on Microbial Stress Responses. Mt. Holyoke, MA. July, 2016. Replication linked expression of the RNA/DNA binding protein, bpuR.
Microbiology, Immunology and Molecular Genetics Departmental Retreat. Berea, KY. May, 2016. Replication linked expression of the RNA/DNA binding protein, bpuR.
Gordon Research Seminar & Conference Biology of Spirochetes. Ventura, CA. January, 2016. Replication linked expression of the RNA/DNA binding protein, bpuR.
International Conference on Lyme Borreliosis and other Tick Borne Diseases. Vienna, Austria. September, 2015. Transcriptional Regulation of bpuR.
Microbiology, Immunology and Molecular Genetics Departmental Retreat. Berea, KY. May, 2015. Transcriptional Regulation of bpuR (An updated model).
Microbiology, Immunology and Molecular Genetics Departmental Retreat. Berea, KY. May, 2014. Transcriptional Regulation of bpuR.
Gordon Research Seminar & Conference Biology of Spirochetes. Ventura, CA. January, 2014.Transcriptional Regulation of bpuR.